PEDIGREE-EXPLORER is a
program package with a focus on genetic-epidemiological
questions as they typically occur prior to linkage analysis.
Especially, the program has been developed and optimized to
(1) analyse thoroughly pedigree structures,
(2) check genotypic marker data for consistency,
(3) create consistent marker sets and
(4) calculate single marker likelihoods for pedigrees.
In doing so, PEDIGREE-EXPLORER can handle
arbitrarily large and complex
pedigrees (i.e. pedigrees with loops)
limited just by the amount of computer memory and computation time.
a data set into its connected components (i.e.
an overview about the affected units (i.e. trios and affected
sib pairs (ASPs)),
- determines the maximal number of generations in a
- finds the longest path from a founder to an offspring,
all loops in a complex pedigree and classifies them as inbreeding
and marriage loops,
an approximately optimal loopbreaker set,
- verifies if a
pedigree is inconsistent with the Mendelian laws of
- generates a
detailed error report specifying the most likely causes of errors,
- determines the
critical genotypes and suggests consistent ones,
generates an error free marker set,
the maximal possible genotype set for each pedigree member,
- calculates the
maximal number of compatible genotype combinations,
single-marker likelihoods for complex pedigrees,
- deals with
autosomal and X-chromosomal markers,
with multiple-occurrences of errors in a single pedigree.